Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cance
Abstract
Colorectal cancer （CRC） tends to occur at older age； however， CRC incidence rates have been rising sharply among young age groups。 The increasing prevalence of obesity is recognized as a major risk， yet the mechanistic underpinnings remain poorly understood。 Using a diet-induced obesity mouse model， we identified obesity-associated molecular changes in the colonic epithelium of young and aged mice， and we further investigated whether the changes were reversed after weight loss。 Transcriptome analysis indicated that obesity-related colonic cellular metabolic switch favoring long-chain fatty acid oxidation happened in young mice， while obesity-associated downregulation of negative feedback regulators of pro-proliferative signaling pathways occurred in older mice。 Strikingly， colonic DNA methylome was pre-programmed by obesity at young age， priming for a tumor-prone gene signature after aging。 Furthermore， obesity-related changes were substantially preserved after short-term weight loss， but they were largely reversed after long-term weight loss。 We provided mechanistic insights into increased CRC risk in obesity。
高脂肪含量飲食引起的肥胖能夠改變（PIONT癌症相關基因）大腸上皮細胞的轉錄組和控制脂肪與碳水化合物的代謝的基因。
結果是：短期透過飲食減肥的小鼠大腸內這種癌症相關基因的高表達任然可以保留，
piont:但是，長期控制飲可以將其成功逆轉
。
所以，人生重很多事情需要堅持，減肥也是堅持中很重要的一部分
！
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